5NV2

Human DNMT3B PWWP domain in complex with N-isopropyl-1,5-dimethylhexylamine (Metron S)

Summary for 5NV2

• Entry DOI: 10.2210/pdb5nv2/pdb
• Descriptor: DNA (cytosine-5)-methyltransferase 3B, (2~{S})-6-methyl-~{N}-propan-2-yl-heptan-2-amine, SULFATE ION, ... (4 entities in total)
• Functional Keywords: dnmt3b pwwp domain, histone binding, beta barrel, ligand, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 34508.84

Authors

Rondelet, G.,Wouters, J. (deposition date: 2017-05-03, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Rondelet, G.,Dal Maso, T.,Maniquet, A.,Themans, Q.,Wouters, J.; Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.029 Å)