5NNJ
Dimer structure of Sortilin ectodomain crystal form 3, 4.0 Angstrom
Summary for 5NNJ
Entry DOI | 10.2210/pdb5nnj/pdb |
Descriptor | Sortilin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | transport receptor, vps10 domain, transport protein |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 4 |
Total formula weight | 331033.48 |
Authors | Leloup, N.O.L.,Janssen, B.J.C. (deposition date: 2017-04-09, release date: 2017-11-29, Last modification date: 2024-01-17) |
Primary citation | Leloup, N.,Lossl, P.,Meijer, D.H.,Brennich, M.,Heck, A.J.R.,Thies-Weesie, D.M.E.,Janssen, B.J.C. Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nat Commun, 8:1708-1708, 2017 Cited by PubMed: 29167428DOI: 10.1038/s41467-017-01485-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4 Å) |
Structure validation
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