5NEE
Crystal structure of human carbonic anhydrase II in complex with the inhibitor 5-[2-(morpholine-4-carbonyl)1,3-oxazol-5-yl)]thiophene-2-sulfonammide
Summary for 5NEE
Entry DOI | 10.2210/pdb5nee/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 5-(2-morpholin-4-ylcarbonyl-1,3-oxazol-5-yl)thiophene-2-sulfonamide, ... (5 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29789.94 |
Authors | Ferraroni, M.,Supuran, C.T.,Krasavin, M. (deposition date: 2017-03-10, release date: 2017-12-06, Last modification date: 2024-01-17) |
Primary citation | Ferraroni, M.,Lucarini, L.,Masini, E.,Korsakov, M.,Scozzafava, A.,Supuran, C.T.,Krasavin, M. 1,3-Oxazole-based selective picomolar inhibitors of cytosolic human carbonic anhydrase II alleviate ocular hypertension in rabbits: Potency is supported by X-ray crystallography of two leads. Bioorg. Med. Chem., 25:4560-4565, 2017 Cited by PubMed: 28728897DOI: 10.1016/j.bmc.2017.06.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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