5MM9
VIM-2_2b. Metallo-beta-Lactamase Inhibitors by Bioisosteric Replacement: Preparation, Activity and Binding
Summary for 5MM9
Entry DOI | 10.2210/pdb5mm9/pdb |
Descriptor | Metallo-beta-lactamase VIM-17, ZINC ION, (2~{R})-2-diethoxyphosphoryl-5-phenyl-pentane-1-thiol, ... (5 entities in total) |
Functional Keywords | inhibition properties, bioisosters, thiols, metallo-beta-lactamase inhibitor, hydrolase |
Biological source | Pseudomonas aeruginosa |
Total number of polymer chains | 2 |
Total formula weight | 52242.30 |
Authors | Skagseth, S.,Akhter, S.,Paulsen, M.H.,Samuelsen, O.,Muhammad, Z.,Leiros, H.-K.S.,Bayer, A. (deposition date: 2016-12-08, release date: 2017-03-29, Last modification date: 2024-01-17) |
Primary citation | Skagseth, S.,Akhter, S.,Paulsen, M.H.,Muhammad, Z.,Lauksund, S.,Leiros, H.S.,Bayer, A. Metallo-beta-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding. Eur J Med Chem, 135:159-173, 2017 Cited by PubMed: 28445786DOI: 10.1016/j.ejmech.2017.04.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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