5LXT

Tubulin-Discodermolide complex

Summary for 5LXT

• Entry DOI: 10.2210/pdb5lxt/pdb
• Related: 4I4T 4I50
• Descriptor: Tubulin alpha-1B chain, (+)-Discodermolide, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: cell cycle, tubulin fold, cytoskeleton, microtubule, discodermolide
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: P81947 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265733.95

Authors

Prota, A.E.,Steinmetz, M.O. (deposition date: 2016-09-22, release date: 2017-03-01, Last modification date: 2024-01-17)

• Primary citation: Prota, A.E.,Bargsten, K.,Redondo-Horcajo, M.,Smith, A.B.,Yang, C.H.,McDaid, H.M.,Paterson, I.,Horwitz, S.B.,Fernando Diaz, J.,Steinmetz, M.O.; Structural Basis of Microtubule Stabilization by Discodermolide.; Chembiochem, 18:905-909, 2017; PubMed: 28207984; DOI: 10.1002/cbic.201600696

Experimental method

X-RAY DIFFRACTION (1.9 Å)