5LV6
N-terminal motif dimerization of EGFR transmembrane domain in bicellar environment
Summary for 5LV6
Entry DOI | 10.2210/pdb5lv6/pdb |
NMR Information | BMRB: 34040 |
Descriptor | Epidermal growth factor receptor (1 entity in total) |
Functional Keywords | epidermal growth factor receptor, bicelles, activation mechanism, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 9467.70 |
Authors | Bragin, P.,Bocharov, E.,Mineev, K.,Bocharova, O.,Arseniev, A. (deposition date: 2016-09-12, release date: 2017-04-05, Last modification date: 2024-06-19) |
Primary citation | Bocharov, E.V.,Bragin, P.E.,Pavlov, K.V.,Bocharova, O.V.,Mineev, K.S.,Polyansky, A.A.,Volynsky, P.E.,Efremov, R.G.,Arseniev, A.S. The Conformation of the Epidermal Growth Factor Receptor Transmembrane Domain Dimer Dynamically Adapts to the Local Membrane Environment. Biochemistry, 56:1697-1705, 2017 Cited by PubMed: 28291355DOI: 10.1021/acs.biochem.6b01085 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report