5LGE
Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032
Summary for 5LGE
Entry DOI | 10.2210/pdb5lge/pdb |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | idh1, allosteric inhibitor, nadp+, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : O75874 |
Total number of polymer chains | 4 |
Total formula weight | 196600.72 |
Authors | Hillig, R.C.,Hars, U.,Korndoerfer, I.P. (deposition date: 2016-07-07, release date: 2017-02-08, Last modification date: 2024-01-10) |
Primary citation | Pusch, S.,Krausert, S.,Fischer, V.,Balss, J.,Ott, M.,Schrimpf, D.,Capper, D.,Sahm, F.,Eisel, J.,Beck, A.C.,Jugold, M.,Eichwald, V.,Kaulfuss, S.,Panknin, O.,Rehwinkel, H.,Zimmermann, K.,Hillig, R.C.,Guenther, J.,Toschi, L.,Neuhaus, R.,Haegebart, A.,Hess-Stumpp, H.,Bauser, M.,Wick, W.,Unterberg, A.,Herold-Mende, C.,Platten, M.,von Deimling, A. Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Acta Neuropathol., 133:629-644, 2017 Cited by PubMed: 28124097DOI: 10.1007/s00401-017-1677-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report