5L79
Crystal structure of MMP12 in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21212.
Summary for 5L79
| Entry DOI | 10.2210/pdb5l79/pdb |
| Related | 4GQL |
| Related PRD ID | PRD_000830 |
| Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (8 entities in total) |
| Functional Keywords | probes for optical imaging, mmp-12, metalloprotease, inflammation, aneurysm, fluorophore, cy5, 5, cyanine, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 20117.41 |
| Authors | Tepshi, L.,Bordenave, T.,Devel, L.,Dive, V.,Stura, E.A. (deposition date: 2016-06-02, release date: 2016-09-14, Last modification date: 2024-01-10) |
| Primary citation | Bordenave, T.,Helle, M.,Beau, F.,Georgiadis, D.,Tepshi, L.,Bernes, M.,Ye, Y.,Levenez, L.,Poquet, E.,Nozach, H.,Razavian, M.,Toczek, J.,Stura, E.A.,Dive, V.,Sadeghi, M.M.,Devel, L. Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes. Bioconjug.Chem., 27:2407-2417, 2016 Cited by PubMed: 27564088DOI: 10.1021/acs.bioconjchem.6b00377 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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