5L6Y
il13 in complex with tralokinumab
Summary for 5L6Y
Entry DOI | 10.2210/pdb5l6y/pdb |
Descriptor | Interleukin-13, tralokinumab FAb digest VH, tralokiumab FAb digest VL, ... (5 entities in total) |
Functional Keywords | il13 antibody tralokinumab asthma, il13, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P35225 |
Total number of polymer chains | 3 |
Total formula weight | 61067.11 |
Authors | Breed, J. (deposition date: 2016-06-01, release date: 2016-12-21, Last modification date: 2024-05-01) |
Primary citation | Popovic, B.,Breed, J.,Rees, D.G.,Gardener, M.J.,Vinall, L.M.,Kemp, B.,Spooner, J.,Keen, J.,Minter, R.,Uddin, F.,Colice, G.,Wilkinson, T.,Vaughan, T.,May, R.D. Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2. J. Mol. Biol., 429:208-219, 2017 Cited by PubMed: 27956146DOI: 10.1016/j.jmb.2016.12.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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