5L6Y

il13 in complex with tralokinumab

Summary for 5L6Y

• Entry DOI: 10.2210/pdb5l6y/pdb
• Descriptor: Interleukin-13, tralokinumab FAb digest VH, tralokiumab FAb digest VL, ... (5 entities in total)
• Functional Keywords: il13 antibody tralokinumab asthma, il13, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P35225
• Total number of polymer chains: 3
• Total formula weight: 61067.11

Authors

Breed, J. (deposition date: 2016-06-01, release date: 2016-12-21, Last modification date: 2017-01-25)

• Primary citation: Popovic, B.,Breed, J.,Rees, D.G.,Gardener, M.J.,Vinall, L.M.,Kemp, B.,Spooner, J.,Keen, J.,Minter, R.,Uddin, F.,Colice, G.,Wilkinson, T.,Vaughan, T.,May, R.D.; Structural Characterisation Reveals Mechanism of IL-13-Neutralising Monoclonal Antibody Tralokinumab as Inhibition of Binding to IL-13R alpha 1 and IL-13R alpha 2.; J. Mol. Biol., 429:208-219, 2017; PubMed: 27956146; DOI: 10.1016/j.jmb.2016.12.005

Experimental method

X-RAY DIFFRACTION (1.99 Å)