5KN5

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

Summary for 5KN5

Entry DOI	10.2210/pdb5kn5/pdb
Descriptor	Epiregulin Antibody LY3016859 Fab Heavy Chain, Epiregulin Antibody LY3016859 Fab Light Chain, Protransforming growth factor alpha, ... (6 entities in total)
Functional Keywords	tgfalpha epiregulin antibody fab, immune system
Biological source	Homo sapiens More
Cellular location	Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135
Total number of polymer chains	6
Total formula weight	103360.96
Authors	Atwell, S.,Boyles, J.S.,Clawson, D.K.,Druzina, Z.,Josef, G.H.,Weichert, K.,Witcher, D.R. (deposition date: 2016-06-27, release date: 2016-08-31, Last modification date: 2016-11-02)
Primary citation	Boyles, J.S.,Atwell, S.,Druzina, Z.,Heuer, J.G.,Witcher, D.R. Structural basis of selectivity and neutralizing activity of a TGF alpha /epiregulin specific antibody. Protein Sci., 25:2028-2036, 2016 Cited by PubMed: 27543934 DOI: 10.1002/pro.3023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation