5KFM

Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: ground state at pH7.0 (K+ MES) with 1 Ca2+ ion

Summary for 5KFM

• Entry DOI: 10.2210/pdb5kfm/pdb
• Descriptor: DNA polymerase eta, DNA (5'-D(*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... (7 entities in total)
• Functional Keywords: in crystallo reaction, dna polymerase, metal ion dependent catalysis, replication, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 55505.32

Authors

Gao, Y.,Yang, W. (deposition date: 2016-06-12, release date: 2016-06-22, Last modification date: 2023-09-27)

• Primary citation: Gao, Y.,Yang, W.; Capture of a third Mg2+ is essential for catalyzing DNA synthesis.; Science, 352:1334-1337, 2016; PubMed: 27284197; DOI: 10.1126/science.aad9633

Experimental method

X-RAY DIFFRACTION (1.6 Å)