5K4X
M. thermoresistible IMPDH in complex with IMP and Compound 1
Summary for 5K4X
Entry DOI | 10.2210/pdb5k4x/pdb |
Descriptor | Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, ~{N}-(2~{H}-indazol-6-yl)-3,5-dimethyl-1~{H}-pyrazole-4-sulfonamide, INOSINIC ACID, ... (4 entities in total) |
Functional Keywords | impdh, guab2, inhibitor-complex, oxidoreductase |
Biological source | Mycobacterium thermoresistibile More |
Total number of polymer chains | 1 |
Total formula weight | 40494.01 |
Authors | Pacitto, A.,Ascher, D.B.,Blundell, T.L. (deposition date: 2016-05-22, release date: 2016-10-19, Last modification date: 2024-05-01) |
Primary citation | Park, Y.,Pacitto, A.,Bayliss, T.,Cleghorn, L.A.,Wang, Z.,Hartman, T.,Arora, K.,Ioerger, T.R.,Sacchettini, J.,Rizzi, M.,Donini, S.,Blundell, T.L.,Ascher, D.B.,Rhee, K.,Breda, A.,Zhou, N.,Dartois, V.,Jonnala, S.R.,Via, L.E.,Mizrahi, V.,Epemolu, O.,Stojanovski, L.,Simeons, F.,Osuna-Cabello, M.,Ellis, L.,MacKenzie, C.J.,Smith, A.R.,Davis, S.H.,Murugesan, D.,Buchanan, K.I.,Turner, P.A.,Huggett, M.,Zuccotto, F.,Rebollo-Lopez, M.J.,Lafuente-Monasterio, M.J.,Sanz, O.,Diaz, G.S.,Lelievre, J.,Ballell, L.,Selenski, C.,Axtman, M.,Ghidelli-Disse, S.,Pflaumer, H.,Bosche, M.,Drewes, G.,Freiberg, G.M.,Kurnick, M.D.,Srikumaran, M.,Kempf, D.J.,Green, S.R.,Ray, P.C.,Read, K.,Wyatt, P.,Barry, C.E.,Boshoff, H.I. Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis. ACS Infect Dis, 3:18-33, 2017 Cited by PubMed: 27704782DOI: 10.1021/acsinfecdis.6b00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
Download full validation report