5K13
Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist
Summary for 5K13
Entry DOI | 10.2210/pdb5k13/pdb |
Descriptor | Retinoic acid receptor alpha, 4-{5-(3-tert-butylphenyl)-1-[4-(methylsulfonyl)phenyl]-1H-pyrazol-3-yl}benzoic acid (3 entities in total) |
Functional Keywords | nhr ligand-binding domain, antagonist, transcription |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P10276 |
Total number of polymer chains | 1 |
Total formula weight | 28163.69 |
Authors | Wang, Y.,Stout, S.L. (deposition date: 2016-05-17, release date: 2016-06-22, Last modification date: 2023-09-27) |
Primary citation | Hughes, N.E.,Bleisch, T.J.,Jones, S.A.,Richardson, T.I.,Doti, R.A.,Wang, Y.,Stout, S.L.,Durst, G.L.,Chambers, M.G.,Oskins, J.L.,Lin, C.,Adams, L.A.,Page, T.J.,Barr, R.J.,Zink, R.W.,Osborne, H.,Montrose-Rafizadeh, C.,Norman, B.H. Identification of potent and selective retinoic acid receptor gamma (RAR gamma ) antagonists for the treatment of osteoarthritis pain using structure based drug design. Bioorg.Med.Chem.Lett., 26:3274-3277, 2016 Cited by PubMed: 27261179DOI: 10.1016/j.bmcl.2016.05.056 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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