5K13

Crystal structure of the RAR alpha ligand-binding domain in complex with an antagonist

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0048384	biological_process	retinoic acid receptor signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 6Q7 A 501

Chain	Residue
A	TRP225
A	GLY301
A	ARG394
A	VAL395
A	MET406
A	PRO407
A	HOH601
A	HOH605
A	HOH629
A	PHE228
A	SER232
A	LEU266
A	LEU269
A	ILE270
A	ARG276
A	PHE286
A	SER287

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"UBR5-degron","evidences":[{"source":"PubMed","id":"37478846","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3A9E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20215566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"19850744","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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