5JM4
Crystal structure of 14-3-3zeta in complex with a cyclic peptide involving an adamantyl and a dicarboxy side chain
Summary for 5JM4
Entry DOI | 10.2210/pdb5jm4/pdb |
Related | 4N7G 4N84 |
Descriptor | 14-3-3 protein zeta/delta, GLN-GLY-MKD-ANG-ASP-MKD-LEU-ASP-LEU-ALA-CLU, BENZOIC ACID, ... (4 entities in total) |
Functional Keywords | peptidomimetic, ppi inhibitor, macrocycle, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 55687.07 |
Authors | Bier, D.,Krueger, D.,Glas, A.,Wallraven, K.,Ottmann, C.,Hennig, S.,Grossmann, T. (deposition date: 2016-04-28, release date: 2017-05-10, Last modification date: 2024-01-10) |
Primary citation | Kruger, D.M.,Glas, A.,Bier, D.,Pospiech, N.,Wallraven, K.,Dietrich, L.,Ottmann, C.,Koch, O.,Hennig, S.,Grossmann, T.N. Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions. J. Med. Chem., 60:8982-8988, 2017 Cited by PubMed: 29028171DOI: 10.1021/acs.jmedchem.7b01221 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.34 Å) |
Structure validation
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