5JFX

Crystal structure of TrkA in complex with PF-06273340

Summary for 5JFX

• Entry DOI: 10.2210/pdb5jfx/pdb
• Related: 5JFS 5JFV 5JFW
• Descriptor: High affinity nerve growth factor receptor, N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide (3 entities in total)
• Functional Keywords: trka inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 35581.47

Authors

Jayasankar, J.,Kurumbail, R.,Skerratt, S.,Brown, D. (deposition date: 2016-04-19, release date: 2017-03-01, Last modification date: 2024-03-06)

• Primary citation: Skerratt, S.E.,Andrews, M.,Bagal, S.K.,Bilsland, J.,Brown, D.,Bungay, P.J.,Cole, S.,Gibson, K.R.,Jones, R.,Morao, I.,Nedderman, A.,Omoto, K.,Robinson, C.,Ryckmans, T.,Skinner, K.,Stupple, P.,Waldron, G.; The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.; J. Med. Chem., 59:10084-10099, 2016; PubMed: 27766865; DOI: 10.1021/acs.jmedchem.6b00850

Experimental method

X-RAY DIFFRACTION (1.63 Å)