5JFX

Crystal structure of TrkA in complex with PF-06273340

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	High affinity nerve growth factor receptor	polymer	308	35101.6	1	UniProt (P04629) Pfam (PF07714) In PDB	Homo sapiens (Human)	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
2	A	N-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide	non-polymer		479.9	1	Chemie (6K4)
3		water	water		18.0	306	Chemie (HOH)

Sequence modifications

A: 502 - 796 (UniProt: P04629)

PDB	External Database	Details
Met 489	-	initiating methionine
His 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
Leu 496	-	expression tag
Val 497	-	expression tag
Pro 498	-	expression tag
Arg 499	-	expression tag
Gly 500	-	expression tag
Ser 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35101.6
Non-Polymers*	Number of molecules	1
	Total formula weight	479.9
All*	Total formula weight	35581.5

*Water molecules are not included.