5JCT
Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24
Summary for 5JCT
Entry DOI | 10.2210/pdb5jct/pdb |
Descriptor | Pirin, FE (III) ION, GLYCEROL, ... (6 entities in total) |
Functional Keywords | cupin, beta-barrel fold, inhibitor, complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : O00625 |
Total number of polymer chains | 1 |
Total formula weight | 35185.60 |
Authors | Ali, S.,van Montfort, R. (deposition date: 2016-04-15, release date: 2017-01-11, Last modification date: 2024-01-10) |
Primary citation | Cheeseman, M.D.,Chessum, N.E.,Rye, C.S.,Pasqua, A.E.,Tucker, M.J.,Wilding, B.,Evans, L.E.,Lepri, S.,Richards, M.,Sharp, S.Y.,Ali, S.,Rowlands, M.,O'Fee, L.,Miah, A.,Hayes, A.,Henley, A.T.,Powers, M.,Te Poele, R.,De Billy, E.,Pellegrino, L.,Raynaud, F.,Burke, R.,van Montfort, R.L.,Eccles, S.A.,Workman, P.,Jones, K. Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. J. Med. Chem., 60:180-201, 2017 Cited by PubMed: 28004573DOI: 10.1021/acs.jmedchem.6b01055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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