5JCT
Crystal Structure of Human Pirin in complex with a Chemical Probe pyrrolidine 24
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003712 | molecular_function | transcription coregulator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006366 | biological_process | transcription by RNA polymerase II |
| A | 0007586 | biological_process | digestion |
| A | 0008127 | molecular_function | quercetin 2,3-dioxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016604 | cellular_component | nuclear body |
| A | 0030099 | biological_process | myeloid cell differentiation |
| A | 0030224 | biological_process | monocyte differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051213 | molecular_function | dioxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FE A 301 |
| Chain | Residue |
| A | HIS56 |
| A | HIS58 |
| A | HIS101 |
| A | GLU103 |
| A | HOH406 |
| A | HOH560 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | TRP190 |
| A | HOH436 |
| A | HOH481 |
| A | HOH497 |
| A | HOH584 |
| A | GLY154 |
| A | GLU155 |
| A | GLN184 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 303 |
| Chain | Residue |
| A | GLU137 |
| A | GLU138 |
| A | ILE139 |
| A | PRO140 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 304 |
| Chain | Residue |
| A | TYR164 |
| A | HOH492 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue 6JQ A 305 |
| Chain | Residue |
| A | GLU18 |
| A | ARG26 |
| A | LEU41 |
| A | ASP43 |
| A | PHE45 |
| A | PHE53 |
| A | PRO54 |
| A | HIS56 |
| A | MET73 |
| A | GLU103 |
| A | GLY113 |
| A | LEU114 |
| A | GLN115 |
| A | TRP117 |
| A | HOH406 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14573596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20711196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ACL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
