5JA7

Human cathepsin K mutant C25S in complex with the allosteric effector NSC94914

Summary for 5JA7

Entry DOI	10.2210/pdb5ja7/pdb
Descriptor	Cathepsin K, [([1,1'-biphenyl]-2-yl)methyl]propanedioic acid, SULFATE ION, ... (6 entities in total)
Functional Keywords	allostery cysteine peptidase proteolysis enzyme regulation collagenase, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Lysosome: P43235
Total number of polymer chains	2
Total formula weight	49962.92
Authors	Novinec, M.,Korenc, M.,Lenarcic, B. (deposition date: 2016-04-12, release date: 2016-11-30, Last modification date: 2024-01-10)
Primary citation	Novinec, M.,Rebernik, M.,Lenarcic, B. An allosteric site enables fine-tuning of cathepsin K by diverse effectors. FEBS Lett., 590:4507-4518, 2016 Cited by PubMed: 27859061 DOI: 10.1002/1873-3468.12495 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation