5JA7
Human cathepsin K mutant C25S in complex with the allosteric effector NSC94914
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cathepsin K | polymer | 223 | 24539.5 | 2 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | C, E (A, B) | [([1,1'-biphenyl]-2-yl)methyl]propanedioic acid | non-polymer | 270.3 | 2 | Chemie (6HM) | |||
| 3 | D, G (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | F (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | H (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 445 | Chemie (HOH) |
Sequence modifications
A, B: -7 - 215 (UniProt: P43235)
| PDB | External Database | Details |
|---|---|---|
| Ser 25 | Cys 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49079.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 883.8 | |
| All* | Total formula weight | 49962.9 |
