5ICK
A unique binding model of FXR LBD with feroline
Summary for 5ICK
Entry DOI | 10.2210/pdb5ick/pdb |
Descriptor | Bile acid receptor, Nuclear receptor coactivator 2, (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate, ... (4 entities in total) |
Functional Keywords | complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 57352.09 |
Authors | |
Primary citation | Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y. A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly Chembiochem, 18:721-725, 2017 Cited by PubMed: 28186695DOI: 10.1002/cbic.201700059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.47 Å) |
Structure validation
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