Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0032052 | molecular_function | bile acid binding |
| B | 0038183 | biological_process | bile acid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue FEZ A 501 |
| Chain | Residue |
| A | PHE284 |
| A | ILE357 |
| A | MET365 |
| A | TYR369 |
| A | HIS447 |
| A | TRP454 |
| A | PHE461 |
| A | LEU465 |
| A | LEU287 |
| A | THR288 |
| A | MET290 |
| A | HIS294 |
| A | MET328 |
| A | PHE329 |
| A | SER332 |
| A | ILE352 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue FEZ B 501 |
| Chain | Residue |
| B | MET265 |
| B | PRO266 |
| B | THR270 |
| B | MET290 |
| B | ASN293 |
| B | HIS294 |
| B | SER332 |
| B | ILE335 |
| B | PHE336 |
| B | LEU348 |
| B | ILE352 |
| B | MET365 |
| B | PHE366 |
| B | TYR369 |
| B | FEZ502 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue FEZ B 502 |
| Chain | Residue |
| B | PHE284 |
| B | LEU287 |
| B | THR288 |
| B | MET290 |
| B | ALA291 |
| B | HIS294 |
| B | MET328 |
| B | PHE329 |
| B | SER332 |
| B | ILE357 |
| B | MET365 |
| B | TYR369 |
| B | HIS447 |
| B | TRP454 |
| B | PHE461 |
| B | LEU465 |
| B | TRP469 |
| B | FEZ501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 448 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 3"} |
