5I46
Factor VIIA in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione
Summary for 5I46
Entry DOI | 10.2210/pdb5i46/pdb |
Descriptor | Coagulation factor VII (Heavy Chain), Coagulation factor VII (Light Chain), (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-8-fluoro-7-hydroxy-4,15,17-trimethyl-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35201.18 |
Authors | |
Primary citation | Glunz, P.W.,Mueller, L.,Cheney, D.L.,Ladziata, V.,Zou, Y.,Wurtz, N.R.,Wei, A.,Wong, P.C.,Wexler, R.R.,Priestley, E.S. Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. J.Med.Chem., 59:4007-4018, 2016 Cited by PubMed: 27015008DOI: 10.1021/acs.jmedchem.6b00244 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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