5I2V
NMR structure of a new G-quadruplex forming sequence within the KRAS proto-oncogene promoter region
Summary for 5I2V
Entry DOI | 10.2210/pdb5i2v/pdb |
NMR Information | BMRB: 30012 |
Descriptor | DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*TP*GP*TP*GP*GP*GP*AP*AP*TP*AP*GP*GP*GP*AP*A)-3'), POTASSIUM ION (2 entities in total) |
Functional Keywords | g-quadruplex, kras, proto-oncogene, cancer target, dna |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 7064.71 |
Authors | Salgado, G.F.,Kerkour, A.,Mergny, J.-L. (deposition date: 2016-02-09, release date: 2016-03-16, Last modification date: 2024-06-19) |
Primary citation | Kerkour, A.,Marquevielle, J.,Ivashchenko, S.,Yatsunyk, L.A.,Mergny, J.L.,Salgado, G.F. High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation. J. Biol. Chem., 292:8082-8091, 2017 Cited by PubMed: 28330874DOI: 10.1074/jbc.M117.781906 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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