5HZE

Mek1 adopts DFG-out conformation when bound to an analog of E6201.

Summary for 5HZE

• Entry DOI: 10.2210/pdb5hze/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, (3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: mek1, e6201, covalent inhibitor, kinase, mek-1, map2k1, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• Total number of polymer chains: 1
• Total formula weight: 39360.91

Authors

Larsen, N.A.,Bloudoff, K. (deposition date: 2016-02-02, release date: 2017-05-03, Last modification date: 2024-10-30)

• Primary citation: Larsen, N.A.,Bloudoff, K.,Subramanian, V.,Nomoto, K.,Wang, J.; Mek1 adopts DFG-out conformation when bound to an analog of E6201.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)