5HZE
Mek1 adopts DFG-out conformation when bound to an analog of E6201.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 348 | 38934.9 | 1 | UniProt (Q02750) Pfam (PF00069) In PDB | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 2 | A | (3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione | non-polymer | 377.4 | 1 | Chemie (E62) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 37 - 383 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Gly 36 | - | expression tag |
| Asn 298 | Ser 298 | engineered mutation |
| Lys 299 | Ser 299 | engineered mutation |
| Phe 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38934.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 426.0 | |
| All* | Total formula weight | 39360.9 |
