5HRP

HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002

Summary for 5HRP

Entry DOI	10.2210/pdb5hrp/pdb
Related	5HOT 5HRN 5HRR 5HRS
Descriptor	Integrase, CACODYLATE ION, SULFATE ION, ... (6 entities in total)
Functional Keywords	viral dna integration, dna binding, ledgf binding, viral protein, transferase-inhibitor complex, transferase/inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1)
Cellular location	Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
Total number of polymer chains	1
Total formula weight	19348.56
Authors	Nolte, R.T. (deposition date: 2016-01-24, release date: 2016-12-14, Last modification date: 2024-03-06)
Primary citation	Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.T.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14:e1002584-e1002584, 2016 Cited by PubMed: 27935939 DOI: 10.1371/journal.pbio.1002584 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation