5HHX

Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide

Summary for 5HHX

• Entry DOI: 10.2210/pdb5hhx/pdb
• Related: 5HHV 5HI3 5HI4 5HI5
• Descriptor: Interleukin-17A, CAT-2000 FAB heavy chain, IL-17A peptide inhibitor, ... (5 entities in total)
• Functional Keywords: il-17, inflammation, inhibitor, complex crystal structure, immune system-inhibitor complex, immune system/inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: Q16552
• Total number of polymer chains: 5
• Total formula weight: 81451.12

Authors

Liu, S. (deposition date: 2016-01-11, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Liu, S.,Desharnais, J.,Sahasrabudhe, P.V.,Jin, P.,Li, W.,Oates, B.D.,Shanker, S.,Banker, M.E.,Chrunyk, B.A.,Song, X.,Feng, X.,Griffor, M.,Jimenez, J.,Chen, G.,Tumelty, D.,Bhat, A.,Bradshaw, C.W.,Woodnutt, G.,Lappe, R.W.,Thorarensen, A.,Qiu, X.,Withka, J.M.,Wood, L.D.; Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.; Sci Rep, 6:26071-26071, 2016; PubMed: 27184415; DOI: 10.1038/srep26071

Experimental method

X-RAY DIFFRACTION (3 Å)