5HHX
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-17A | polymer | 138 | 15770.9 | 2 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (Human) | IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | C (H) | CAT-2000 FAB heavy chain | polymer | 237 | 25053.9 | 1 | Homo sapiens | ||
| 3 | D (I) | IL-17A peptide inhibitor | polymer | 16 | 1849.1 | 1 | Synthetic construct | ||
| 4 | E (L) | CAT-2000 FAB light chain | polymer | 214 | 23006.3 | 1 | Homo sapiens | ||
| 5 | F, G, H (A, H, L) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: -5 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Asp -5 | Glu 18 | expression tag |
| Pro -4 | Ala 19 | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 81451.1 | |
| All* | Total formula weight | 81451.1 |
