5HHW
Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl)cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine.
Summary for 5HHW
Entry DOI | 10.2210/pdb5hhw/pdb |
Descriptor | Insulin receptor, 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{R})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, insulin receptor, kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P06213 |
Total number of polymer chains | 1 |
Total formula weight | 35448.66 |
Authors | Scheufler, C.,Izaac, A.,Stauffer, F. (deposition date: 2016-01-11, release date: 2016-04-13, Last modification date: 2024-05-01) |
Primary citation | Stauffer, F.,Cowan-Jacob, S.W.,Scheufler, C.,Furet, P. Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors. Bioorg.Med.Chem.Lett., 26:2065-2067, 2016 Cited by PubMed: 26951750DOI: 10.1016/j.bmcl.2016.02.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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