5HH4
Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor
Summary for 5HH4
Entry DOI | 10.2210/pdb5hh4/pdb |
Descriptor | Beta-lactamase IMP-1, ZINC ION, 6-(phosphonomethyl)pyridine-2-carboxylic acid, ... (6 entities in total) |
Functional Keywords | inhibitor, carbapenamase, pyridine, phosphonate, antibiotic resistance, hydrolase |
Biological source | Serratia marcescens |
Total number of polymer chains | 4 |
Total formula weight | 102322.22 |
Authors | Hinchliffe, P.,Spencer, J. (deposition date: 2016-01-09, release date: 2017-01-18, Last modification date: 2024-01-10) |
Primary citation | Hinchliffe, P.,Tanner, C.A.,Krismanich, A.P.,Labbe, G.,Goodfellow, V.J.,Marrone, L.,Desoky, A.Y.,Calvopina, K.,Whittle, E.E.,Zeng, F.,Avison, M.B.,Bols, N.C.,Siemann, S.,Spencer, J.,Dmitrienko, G.I. Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates. Biochemistry, 57:1880-1892, 2018 Cited by PubMed: 29485857DOI: 10.1021/acs.biochem.7b01299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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