5HH4
Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Beta-lactamase IMP-1 | polymer | 230 | 25285.8 | 4 | UniProt (P52699) Pfam (PF00753) | Serratia marcescens | BLAIMP,Beta-lactamase type II,Penicillinase, Class B1 Metallo-beta-lactamase IMP-1 |
| 2 | E, F, H, I, M... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, J (A, B) | 6-(phosphonomethyl)pyridine-2-carboxylic acid | non-polymer | 217.1 | 2 | Chemie (60M) | |||
| 4 | K (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | L, O, R (B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 624 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 228 (UniProt: P52699)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Asn 225 | Lys 243 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101143.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1179.2 | |
| All* | Total formula weight | 102322.2 |
