5HE3
Bovine GRK2 in complex with Gbetagamma subunits and CCG224411
Summary for 5HE3
Entry DOI | 10.2210/pdb5he3/pdb |
Related | 5HE0 5HE1 5HE2 |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | rgs, kinase, ph, wd-40, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bos taurus (Bovine) More |
Total number of polymer chains | 3 |
Total formula weight | 120489.86 |
Authors | Cato, M.C.,Tesmer, J.J.G. (deposition date: 2016-01-05, release date: 2016-05-11, Last modification date: 2024-03-06) |
Primary citation | Waldschmidt, H.V.,Homan, K.T.,Cruz-Rodriguez, O.,Cato, M.C.,Waninger-Saroni, J.,Larimore, K.M.,Cannavo, A.,Song, J.,Cheung, J.Y.,Kirchhoff, P.D.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59:3793-3807, 2016 Cited by PubMed: 27050625DOI: 10.1021/acs.jmedchem.5b02000 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.74 Å) |
Structure validation
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