5H74

Crystal structure of T2R-TTL-14b complex

Summary for 5H74

• Entry DOI: 10.2210/pdb5h74/pdb
• Descriptor: Tubulin alpha-1B chain, (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: tubulin, complex, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 Q6B856; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 266218.17

Authors

Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. (deposition date: 2016-11-17, release date: 2017-11-22, Last modification date: 2024-03-20)

• Primary citation: Wang, Y.,Yu, Y.,Chen, Q.,Yang, J.; Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)