5GGV
CTLA-4 in complex with tremelimumab Fab
Summary for 5GGV
Entry DOI | 10.2210/pdb5ggv/pdb |
Related | 5GGQ 5GGR 5GGS 5GGT 5GGU |
Descriptor | light chain, heavy chain, Cytotoxic T-lymphocyte protein 4, ... (4 entities in total) |
Functional Keywords | antibody, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P16410 |
Total number of polymer chains | 3 |
Total formula weight | 62868.27 |
Authors | Heo, Y.S. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2016-11-16) |
Primary citation | Lee, J.Y.,Lee, H.T.,Shin, W.,Chae, J.,Choi, J.,Kim, S.H.,Lim, H.,Won Heo, T.,Park, K.Y.,Lee, Y.J.,Ryu, S.E.,Son, J.Y.,Lee, J.U.,Heo, Y.S. Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy Nat Commun, 7:13354-13354, 2016 Cited by PubMed: 27796306DOI: 10.1038/ncomms13354 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.998 Å) |
Structure validation
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