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5GGV

CTLA-4 in complex with tremelimumab Fab

Summary for 5GGV
Entry DOI10.2210/pdb5ggv/pdb
Related5GGQ 5GGR 5GGS 5GGT 5GGU
Descriptorlight chain, heavy chain, Cytotoxic T-lymphocyte protein 4, ... (4 entities in total)
Functional Keywordsantibody, immune system
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane ; Single-pass type I membrane protein : P16410
Total number of polymer chains3
Total formula weight62868.27
Authors
Heo, Y.S. (deposition date: 2016-06-16, release date: 2016-11-09, Last modification date: 2016-11-16)
Primary citationLee, J.Y.,Lee, H.T.,Shin, W.,Chae, J.,Choi, J.,Kim, S.H.,Lim, H.,Won Heo, T.,Park, K.Y.,Lee, Y.J.,Ryu, S.E.,Son, J.Y.,Lee, J.U.,Heo, Y.S.
Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7:13354-13354, 2016
Cited by
PubMed: 27796306
DOI: 10.1038/ncomms13354
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.998 Å)
Structure validation

217705

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