5G5J
Crystal structure of human CYP3A4 bound to metformin
Summary for 5G5J
Entry DOI | 10.2210/pdb5g5j/pdb |
Descriptor | CYTOCHROME P450 3A4, Metformin, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, monooxygenase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P08684 |
Total number of polymer chains | 1 |
Total formula weight | 56503.46 |
Authors | Sevrioukova, I. (deposition date: 2016-05-25, release date: 2017-06-07, Last modification date: 2024-01-10) |
Primary citation | Guo, Z.,Sevrioukova, I.F.,Denisov, I.G.,Zhang, X.,Chiu, T.L.,Thomas, D.G.,Hanse, E.A.,Cuellar, R.A.D.,Grinkova, Y.V.,Langenfeld, V.W.,Swedien, D.S.,Stamschror, J.D.,Alvarez, J.,Luna, F.,Galvan, A.,Bae, Y.K.,Wulfkuhle, J.D.,Gallagher, R.I.,Petricoin, E.F.,Norris, B.,Flory, C.M.,Schumacher, R.J.,O'Sullivan, M.G.,Cao, Q.,Chu, H.,Lipscomb, J.D.,Atkins, W.M.,Gupta, K.,Kelekar, A.,Blair, I.A.,Capdevila, J.H.,Falck, J.R.,Sligar, S.G.,Poulos, T.L.,Georg, G.I.,Ambrose, E.,Potter, D.A. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol, 24:1259-1275.e6, 2017 Cited by PubMed: 28919040DOI: 10.1016/j.chembiol.2017.08.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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