5FUM
Mus musculus acetylcholinesterase in complex with AL200
Summary for 5FUM
Entry DOI | 10.2210/pdb5fum/pdb |
Descriptor | ACETYLCHOLINESTERASE, 2-(biphenyl-4-yloxy)-1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]ethanone, 2-(2-METHOXYETHOXY)ETHANOL, ... (5 entities in total) |
Functional Keywords | hydrolase, acetylcholinesterase, vector control, insecticide, selective, malaria, dengue |
Biological source | MUS MUSCULUS (HOUSE MOUSE) |
Cellular location | Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836 |
Total number of polymer chains | 2 |
Total formula weight | 122238.24 |
Authors | Knutsson, S.,Engdahl, C.,Ekstrom, F.,Linusson, A. (deposition date: 2016-01-28, release date: 2016-09-21, Last modification date: 2018-01-17) |
Primary citation | Engdahl, C.,Knutsson, S.,Ekstrom, F.J.,Linusson, A. Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes. J.Med.Chem., 17:2724-, 2016 Cited by PubMed: 27598521DOI: 10.1021/ACS.JMEDCHEM.6B00967 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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