5FI7
Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide
Summary for 5FI7
Entry DOI | 10.2210/pdb5fi7/pdb |
Related | 5FI2 5FI6 |
Descriptor | Glutaminase kidney isoform, mitochondrial, 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide (3 entities in total) |
Functional Keywords | glutaminase c, complex, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 238873.59 |
Authors | Huang, Q.,Cerione, R. (deposition date: 2015-12-22, release date: 2016-05-11, Last modification date: 2023-09-27) |
Primary citation | McDermott, L.A.,Iyer, P.,Vernetti, L.,Rimer, S.,Sun, J.,Boby, M.,Yang, T.,Fioravanti, M.,O'Neill, J.,Wang, L.,Drakes, D.,Katt, W.,Huang, Q.,Cerione, R. Design and evaluation of novel glutaminase inhibitors. Bioorg.Med.Chem., 24:1819-1839, 2016 Cited by PubMed: 26988803DOI: 10.1016/j.bmc.2016.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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