5FI7

Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Glutaminase kidney isoform, mitochondrial	polymer	539	59457.6	4	UniProt (O94925) Pfam (PF17959) Pfam (PF04960)	Homo sapiens (human)	GLS,K-glutaminase,L-glutamine amidohydrolase
2	E, F (A, C)	2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide	non-polymer		521.6	2	Chemie (5XZ)
3	G, H, I, J (A, B, C, D)	water	water		18.0	202	Chemie (HOH)

Sequence modifications

A, B, C, D: 71 - 597 (UniProt: O94925)

PDB	External Database	Details
Met 59	-	initiating methionine
Arg 60	-	expression tag
Gly 61	-	expression tag
Ser 62	-	expression tag
His 63	-	expression tag
His 64	-	expression tag
His 65	-	expression tag
His 66	-	expression tag
His 67	-	expression tag
His 68	-	expression tag
Gly 69	-	expression tag
Ser 70	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	237830.4
Non-Polymers*	Number of molecules	2
	Total formula weight	1043.2
All*	Total formula weight	238873.6

*Water molecules are not included.