5FD2
B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor
Summary for 5FD2
Entry DOI | 10.2210/pdb5fd2/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{H}-purine (3 entities in total) |
Functional Keywords | phosphotransferase, inhibitor, melanoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 69944.66 |
Authors | Whittington, D.A.,Epstein, L.F. (deposition date: 2015-12-15, release date: 2016-05-04, Last modification date: 2024-03-06) |
Primary citation | Liu, L.,Lee, M.R.,Kim, J.L.,Whittington, D.A.,Bregman, H.,Hua, Z.,Lewis, R.T.,Martin, M.W.,Nishimura, N.,Potashman, M.,Yang, K.,Yi, S.,Vaida, K.R.,Epstein, L.F.,Babij, C.,Fernando, M.,Carnahan, J.,Norman, M.H. Purinylpyridinylamino-based DFG-in/ alpha C-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling. Bioorg.Med.Chem., 24:2215-2234, 2016 Cited by PubMed: 27085672DOI: 10.1016/j.bmc.2016.03.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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