5FD2

B-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein kinase B-raf	polymer	300	34525.9	2	UniProt (P15056) Pfam (PF07714)	Homo sapiens (Human)	Proto-oncogene B-Raf,p94,v-Raf murine sarcoma viral oncogene homolog B1
2	C, D (A, B)	6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{H}-purine	non-polymer		446.4	2	Chemie (5XJ)
3	E, F (A, B)	water	water		18.0	32	Chemie (HOH)

Sequence modifications

A, B: 433 - 726 (UniProt: P15056)

PDB	External Database	Details
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69051.8
Non-Polymers*	Number of molecules	2
	Total formula weight	892.9
All*	Total formula weight	69944.7

*Water molecules are not included.