5FBX
Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor
Summary for 5FBX
Entry DOI | 10.2210/pdb5fbx/pdb |
Descriptor | Bromodomain-containing protein 4, (3~{S})-5-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methyl-3-phenyl-3~{H}-isoindol-1-one (3 entities in total) |
Functional Keywords | brg1-associated factor 180, baf180, transcription, chromatin remodeling |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15417.75 |
Authors | Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S. (deposition date: 2015-12-14, release date: 2015-12-30, Last modification date: 2024-01-10) |
Primary citation | Tallant, C.,Clark, P.G.K.,Siejka, P.,Fedorov, O.,Nowak, R.,Srikannathasan, V.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Brennan, P.E.,Dixon, D.,Knapp, S. Crystal structure of the first bromodomain of human BRD4 in complex with PNZ5 isoxazole inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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