5F96
Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.12 in complex with HIV-1 clade A/E 93TH057 gp120
Summary for 5F96
Entry DOI | 10.2210/pdb5f96/pdb |
Related | 4RWY 4RX4 4YFL |
Descriptor | clade A/E 93TH057 HIV-1 gp120 core, HEAVY CHAIN OF ANTIBODY CH235.12, LIGHT CHAIN OF ANTIBODY CH235.12, ... (6 entities in total) |
Functional Keywords | hiv-1, antibody, ch235 lineage, vh1-46 germline, immune system |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 3 |
Total formula weight | 90351.21 |
Authors | Zhou, T.,Kwong, P.D. (deposition date: 2015-12-09, release date: 2016-03-09, Last modification date: 2020-07-29) |
Primary citation | Bonsignori, M.,Zhou, T.,Sheng, Z.,Chen, L.,Gao, F.,Joyce, M.G.,Ozorowski, G.,Chuang, G.Y.,Schramm, C.A.,Wiehe, K.,Alam, S.M.,Bradley, T.,Gladden, M.A.,Hwang, K.K.,Iyengar, S.,Kumar, A.,Lu, X.,Luo, K.,Mangiapani, M.C.,Parks, R.J.,Song, H.,Acharya, P.,Bailer, R.T.,Cao, A.,Druz, A.,Georgiev, I.S.,Kwon, Y.D.,Louder, M.K.,Zhang, B.,Zheng, A.,Hill, B.J.,Kong, R.,Soto, C.,Mullikin, J.C.,Douek, D.C.,Montefiori, D.C.,Moody, M.A.,Shaw, G.M.,Hahn, B.H.,Kelsoe, G.,Hraber, P.T.,Korber, B.T.,Boyd, S.D.,Fire, A.Z.,Kepler, T.B.,Shapiro, L.,Ward, A.B.,Mascola, J.R.,Liao, H.X.,Kwong, P.D.,Haynes, B.F. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell, 165:449-463, 2016 Cited by PubMed: 26949186DOI: 10.1016/j.cell.2016.02.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2407 Å) |
Structure validation
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