5F3H
Structure of myostatin in complex with humanized RK35 antibody
Summary for 5F3H
Entry DOI | 10.2210/pdb5f3h/pdb |
Related | 5F3B |
Descriptor | humanized RK35 antibody heavy chain, humanized RK35 antibody light chain, Growth/differentiation factor 8 (3 entities in total) |
Functional Keywords | myostatin, antibody, complex, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Mus musculus More |
Cellular location | Secreted: O14793 |
Total number of polymer chains | 12 |
Total formula weight | 236204.50 |
Authors | Parris, K.D.,Mosyak, L. (deposition date: 2015-12-02, release date: 2016-09-28, Last modification date: 2023-09-27) |
Primary citation | Apgar, J.R.,Mader, M.,Agostinelli, R.,Benard, S.,Bialek, P.,Johnson, M.,Gao, Y.,Krebs, M.,Owens, J.,Parris, K.,St Andre, M.,Svenson, K.,Morris, C.,Tchistiakova, L. Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8:1302-1318, 2016 Cited by PubMed: 27625211DOI: 10.1080/19420862.2016.1215786 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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