5F2E
Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C
Summary for 5F2E
Entry DOI | 10.2210/pdb5f2e/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, GLYCEROL, ... (7 entities in total) |
Functional Keywords | small gtpase domain, covalent inhibitor bound, switch ii pocket, gdp bound, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 1 |
Total formula weight | 20512.49 |
Authors | Patricelli, M.P.,Janes, M.R.,Li, L.-S.,Hansen, R.,Peters, U.,Kessler, L.V.,Chen, Y.,Kucharski, J.M.,Feng, J.,Ely, T.,Chen, J.H.,Firdaus, S.J.,Babbar, A.,Ren, P.,Liu, Y. (deposition date: 2015-12-01, release date: 2016-01-13, Last modification date: 2023-09-27) |
Primary citation | Patricelli, M.P.,Janes, M.R.,Li, L.S.,Hansen, R.,Peters, U.,Kessler, L.V.,Chen, Y.,Kucharski, J.M.,Feng, J.,Ely, T.,Chen, J.H.,Firdaus, S.J.,Babbar, A.,Ren, P.,Liu, Y. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6:316-329, 2016 Cited by PubMed: 26739882DOI: 10.1158/2159-8290.CD-15-1105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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