5E1E
Human JAK1 kinase in complex with compound 30 at 2.30 Angstroms resolution
Summary for 5E1E
Entry DOI | 10.2210/pdb5e1e/pdb |
Descriptor | Tyrosine-protein kinase JAK1, DI(HYDROXYETHYL)ETHER, 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system; Peripheral membrane protein: P23458 |
Total number of polymer chains | 2 |
Total formula weight | 67924.29 |
Authors | Ferguson, A.D. (deposition date: 2015-09-29, release date: 2015-11-25, Last modification date: 2015-12-30) |
Primary citation | Vasbinder, M.M.,Alimzhanov, M.,Augustin, M.,Bebernitz, G.,Bell, K.,Chuaqui, C.,Deegan, T.,Ferguson, A.D.,Goodwin, K.,Huszar, D.,Kawatkar, A.,Kawatkar, S.,Read, J.,Shi, J.,Steinbacher, S.,Steuber, H.,Su, Q.,Toader, D.,Wang, H.,Woessner, R.,Wu, A.,Ye, M.,Zinda, M. Identification of azabenzimidazoles as potent JAK1 selective inhibitors. Bioorg.Med.Chem.Lett., 26:60-67, 2016 Cited by PubMed: 26614408DOI: 10.1016/j.bmcl.2015.11.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report