Summary for 6ISD
| Entry DOI | 10.2210/pdb6isd/pdb |
| Descriptor | 4-hydroxyphenylpyruvate dioxygenase, 2-[2-chloro-4-(methylsulfonyl)benzoyl]cyclohexane-1,3-dione, COBALT (II) ION, ... (4 entities in total) |
| Functional Keywords | 4-hydroxyphenylpyruvate dioxygenase, slow binding inhibitors, drug design, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
| Biological source | Arabidopsis thaliana (Mouse-ear cress) |
| Total number of polymer chains | 2 |
| Total formula weight | 98523.07 |
| Authors | Yang, W.C.,Yang, G.F. (deposition date: 2018-11-16, release date: 2018-11-28, Last modification date: 2023-11-22) |
| Primary citation | Lin, H.Y.,Yang, J.F.,Wang, D.W.,Hao, G.F.,Dong, J.Q.,Wang, Y.X.,Yang, W.C.,Wu, J.W.,Zhan, C.G.,Yang, G.F. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J., 286:975-990, 2019 Cited by PubMed: 30632699DOI: 10.1111/febs.14747 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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