5D7R
Crystal structure of the ATP binding domain of S. aureus GyrB complexed with a ligand
Summary for 5D7R
Entry DOI | 10.2210/pdb5d7r/pdb |
Related | 5CPH 5CTU 5CTW 5CTX 5CTY 5D6P 5D6Q 5D7C 5D7D |
Descriptor | DNA gyrase subunit B, MAGNESIUM ION, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | dna gyrase, gyrb, ligand, structure-based design, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm : P0A0K8 |
Total number of polymer chains | 2 |
Total formula weight | 49039.56 |
Authors | Zhang, J.,Yang, Q.,Cross, J.B.,Romero, J.A.C.,Ryan, M.D.,Lippa, B.,Dolle, R.E.,Andersen, O.A.,Barker, J.,Cheng, R.K.,Kahmann, J.,Felicetti, B.,Wood, M.,Scheich, C. (deposition date: 2015-08-14, release date: 2015-11-18, Last modification date: 2023-09-27) |
Primary citation | Zhang, J.,Yang, Q.,Romero, J.A.,Cross, J.,Wang, B.,Poutsiaka, K.M.,Epie, F.,Bevan, D.,Wu, Y.,Moy, T.,Daniel, A.,Chamberlain, B.,Carter, N.,Shotwell, J.,Arya, A.,Kumar, V.,Silverman, J.,Nguyen, K.,Metcalf, C.A.,Ryan, D.,Lippa, B.,Dolle, R.E. Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. Acs Med.Chem.Lett., 6:1080-1085, 2015 Cited by PubMed: 26487916DOI: 10.1021/acsmedchemlett.5b00266 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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