5CT7
BRAF in Complex with RAF265
Summary for 5CT7
Entry DOI | 10.2210/pdb5ct7/pdb |
Descriptor | Serine/threonine-protein kinase B-raf, 1-methyl-5-({2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine (2 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P15056 |
Total number of polymer chains | 2 |
Total formula weight | 64864.59 |
Authors | Appleton, B.A. (deposition date: 2015-07-23, release date: 2015-09-09, Last modification date: 2024-03-06) |
Primary citation | Williams, T.E.,Subramanian, S.,Verhagen, J.,McBride, C.M.,Costales, A.,Sung, L.,Antonios-McCrea, W.,McKenna, M.,Louie, A.K.,Ramurthy, S.,Levine, B.,Shafer, C.M.,Machajewski, T.,Renhowe, P.A.,Appleton, B.A.,Amiri, P.,Chou, J.,Stuart, D.,Aardalen, K.,Poon, D. Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. Acs Med.Chem.Lett., 6:961-965, 2015 Cited by PubMed: 26396681DOI: 10.1021/ml500526p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.17 Å) |
Structure validation
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